KomivesLab

Specializing in Biophysics Research

Other Projects

The LDL receptor-related protein

Guttman, M. and Komives, EA (2011) Structure, dynamics and binding of the LA45 module pair of the Low Density Lipoprotein Receptor suggest an important role for LA4 in ligand release. Biochemistry 50(51):11001-8. PMC3263374

Mulvihill, M, Guttman, M. and Komives EA (2011) Protein Interactions among Fe65, the Low-Density Lipoprotein Receptor-Related Protein, and the Amyloid Precursor Protein Biochemistry 50(28):6208-16. PMC3139566

Guttman, M., Prieto, J. H., Handel. T. M., Domaille, P. J. & Komives, E. A. (2010) Structure of the Minimal Interface Between ApoE and LRP J. Mol. Biol., 398, 306-319.

Guttman, M., Prieto, J. H., Croy, J. E. & Komives, E. A. (2010) Decoding of Lipoprotein-Receptor Interactions: Properties of Ligand Binding Modules Governing Interactions with Apolipoprotein E Biochemistry 49, 1207-1216.

Guttman, M., Betts, G. N, Barnes, H., Ghassemian, M., Van der geer, P. & Komives, E. A. (2009) Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1 Proteomics, 9, 5016-5028.

Betts, G. N, van der Geer, P. & Komives, E. A. (2008) Structural and Functional Consequences of Tyrosine Phosphorylation in the LRP1 Cytoplasmic Domain. J Biol Chem. 283, 15656-64.

Croy, J. E., Brandon, T. & Komives, E. A. (2004) Two apolipoprotein E mimetic peptides, apoE(130-149) and apoE(141-155)2, bind to LRP1. Biochemistry 43, 7328-35.

Croy, J. E., Shin, W. D., Knauer, M. F., Knauer, D. J., & Komives, E. A. (2003) All three LDL receptor homology regions of the LDL receptor-related protein (LRP) bind multiple ligands. Biochemistry 42, 13049-57.

Mentz, S., DeLacalle, S. Baerga-Ortiz, A. J., Knauer, M. F., Knauer, D. J. & Komives, E. A. (1999)
Mechanism of thrombin clearance by human astrocytoma cells.
J. Neurochemistry 72, 980-987.

Pichia Pastoris Expression

Wood, M. J. & Komives, E. A. (1999) Production of Large Quantities of Isotopically-Labeled Protein in Pichia pastoris by Fermentation J. Biomolecular NMR 13, 149 – 159.

Greenwald, J., Le, V., Corrigan, A., Fischer, W., Komives, E., Vale, W., Choe, S. (1998) Characterization of the extracellular ligand-binding domain of the type II activin receptor. Biochemistry 37, 16711 – 16718.

Gleeson, M.A. G., White. C. E., Meininger, D. P. & Komives, E. A. (1997) Generation of Protease Deficient Strains of Pichia pastoris and Their Use in Heterologous Protein Expression Methods in Molecular Biology 103, 81 – 94.

White, C. E., Hunter, M. J., Meininger, D. P., White, L. R. & Komives, E. A. (1995) Large Scale Expression, Purification and Characterization of the Smallest Active Fragment of Thrombomodulin: The Roles of the Sixth Domain and of Methionine-388 Protein Engineering 8, 1177 – 1187.