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Work in the Komives Lab is focused on understanding the parameters that govern protein-protein interactions mediated by non-globular proteins. Four(4) main systems are currently under study. We were the first lab to do amide H/D exchange to understand what happens to the solvent accessibility of the interface during protein-protein interactions. We developed methods to do H/D exchange by MALDI mass spectrometry, a readily available experimental set-up for non-mass spec experts. The lab consists of three postdoctoral fellows, four graduate students and five undergraduate students. Our lab oversees the Biophysics Instrumentation Facility, which contains a BIAcore 3000, a Beckman XL-I Analytical Ultracentrifuge, a Stopped-Flow CD and a MicroCal VP Isothermal Titration Calorimeter. We also oversee the Biomolecular Mass Spectrometry at UCSD which includes a Voyager MALDI-TOF Mass Spectrometer, two Q-STAR q-TOF Mass Spectrometers and a MALDI TOF-TOF mass spectrometer. The lab is also a member of the NMR User Group at UCSD.